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CO.STARTERS Accelerator Program

If you’re an aspiring entrepreneur, or a seasoned entrepreneur looking to launch a new product or service, CO.STARTERS is for you.

The FIRST cohort starts January 12, 2021.



The Sioux Falls startup community starts here.

Startup Sioux Falls and Zeal: working to build a stronger startup community.

Join the community and start building something great.



Get started and reach out to those who can help across the region.



Work in a place of inspiration, surrounded by other entrepreneurs.



A community of collaboration, encouragement, education, growth, innovation, and ideas.

Community Members

More than 7,000 small business owners, startup founders and entrepreneurs are actively participating in the Startup Sioux Falls Facebook group.

Startup Organizations

40+ organizations, including non-profits, state agencies, and community groups are working together to help startups and small businesses succeed in Sioux Falls.

Unique Events

There are 3 weekly events, 2 monthly events and 7 annual events geared toward entrepreneurs and small business owners in the Sioux Falls community.

Zeal Facility

Space for your work to flourish.

Available Services

Giving you that boost of support.

Startup Community News

Hear what's happening in the community.


South Dakota biopharma startup acquired by Gamma Biosciences

By Andrea Van Essen | November 23, 2020

Nanopareil LLC, a biopharma startup based in South Dakota, was recently acquired by Gamma Biosciences, a life sciences tools platform. The acquisition will accelerate Nanopareil in the development and marketing of their product—an advanced purification method for monoclonal antibodies and other next-generation biopharmaceuticals.  Nanopareil has patented a nanofiber-based purification membrane for use in biopharmaceutical processing.…

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Startup Sioux Falls and Zeal Sponsors

These organizations provide financial support for Startup Sioux Falls and the Zeal Center for Entrepreneursihp